Recent Study Pinpoints Source of mRNA Vaccine Side Effects
Australian researchers have unveiled the reasons behind the side effects associated with messenger ribonucleic acid (mRNA) vaccines, including headaches and fevers. This breakthrough, which they claim could enhance the efficacy of vaccines, marks an important advancement in understanding vaccine reactions.
TroibNews 
Australian researchers have identified the reasons behind the side effects commonly associated with messenger ribonucleic acid (mRNA) vaccines, such as headaches and fevers, in a significant finding that has the potential to enhance vaccine efficacy.
A study released by Melbourne's Peter Doherty Institute for Infection and Immunity and RMIT University on Thursday presents a comprehensive analysis of how mRNA vaccines circulate and decompose within the human bloodstream.
While mRNA vaccines are intended to remain in the lymph nodes to stimulate the production of antibodies against infections, the research—based on 156 blood samples from 19 individuals collected over 28 days following an mRNA COVID-19 booster shot—revealed that a small fraction of the vaccine managed to enter the bloodstream.
"The extent to which the vaccine enters the bloodstream varies between individuals, which may explain some of the side effects such as fever, headache, and fatigue, reported after vaccination," stated Yi Ju, a co-author from RMIT University's School of Science.
"This variation in vaccine presence in the blood could trigger inflammatory responses, leading to these side effects in certain individuals."
The initial mRNA vaccines received approval for COVID-19 in 2020. Unlike traditional vaccines that utilize a weakened virus, mRNA vaccines deploy genetic instructions to stimulate the body to create a protein that instigates an immune response.
Since their launch, mRNA vaccine technology has been applied by scientists to formulate vaccines and therapies for other illnesses, including cancer.
The researchers behind this new study emphasized that their findings provide critical insights aimed at enhancing the safety and effectiveness of mRNA vaccines.
James del Carmen for TROIB News
A study released by Melbourne's Peter Doherty Institute for Infection and Immunity and RMIT University on Thursday presents a comprehensive analysis of how mRNA vaccines circulate and decompose within the human bloodstream.
While mRNA vaccines are intended to remain in the lymph nodes to stimulate the production of antibodies against infections, the research—based on 156 blood samples from 19 individuals collected over 28 days following an mRNA COVID-19 booster shot—revealed that a small fraction of the vaccine managed to enter the bloodstream.
"The extent to which the vaccine enters the bloodstream varies between individuals, which may explain some of the side effects such as fever, headache, and fatigue, reported after vaccination," stated Yi Ju, a co-author from RMIT University's School of Science.
"This variation in vaccine presence in the blood could trigger inflammatory responses, leading to these side effects in certain individuals."
The initial mRNA vaccines received approval for COVID-19 in 2020. Unlike traditional vaccines that utilize a weakened virus, mRNA vaccines deploy genetic instructions to stimulate the body to create a protein that instigates an immune response.
Since their launch, mRNA vaccine technology has been applied by scientists to formulate vaccines and therapies for other illnesses, including cancer.
The researchers behind this new study emphasized that their findings provide critical insights aimed at enhancing the safety and effectiveness of mRNA vaccines.
James del Carmen for TROIB News
